Cellular & Molecular Immunology. 2004 Feb, Vol.1, No.1, pp.71-76.
Anti-CD137 Monoclonal Antibody Promotes the Direct
Anti-Tumor Effect Mediated by Peripheral Blood-Derived
Human Dendritic Cells in vitro
Lining Zhang1, 2, Qun Wang1, Xiaoyan Wang1, Peifang Ding1, Jing Song1, Chunhong Ma1 and
Wensheng Sun1
1Immunology Institute of Shandong University, Jinan, Shandong 250012,
China.
2Corresponding to: Dr. Lining Zhang, Institute of Immunology, Medical
School of Shandong University, 44# Wenhua Xilu, Jinan, Shandong
250012, China. Tel: +86-531-838-2038, Fax: +86-531-838-0228, E-mail:
immuno@sdu.edu.cn or zhang_lining@hotmail. com.
CD137, a costimulatory factor of TNFR family, is expressed on activated T cells and freshly isolated mouse
dendritic cells (DCs). To date, there are only limited data dealing with the expression and the effect of CD137 on
human DCs. We report in this work that CD137 can coexpress with CD137L on immature peripheral
blood-derived human DCs (9.77%). The mature DCs stimulated by LPS showed a much higher level of CD137
expression (36.06%). Ligation of CD137 on the surface of DCs with anti-CD137 monoclonal antibody (mAb)
could enhance the direct anti-tumor effect mediated by human DCs in vitro. The agonistic anti-CD137 mAb was
able to elevate by about 20% of the DC-mediated inhibition of tumor growth in five tumor cell lines. These
results indicate that the appliance of anti-CD137 mAb might be used as a new strategy for tumor
immunotherapy.
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