Cellular & Molecular Immunology. 2004 Feb, Vol.1, No.1, pp.57-62.
Kinetics of the Phenotype and Function of Murine Peritoneal
Macrophages Following Acute Inflammation
Qingli Wu1, Yonghong Feng1, Yifu Yang1, Jingliu1, Wenliang Zhou1, Peilan He1, Ru Zhou1,
Xiaoyu Li1 and Jianping Zou1, 2
1Laboratory of Immunopharmacology & State Key Laboratory of DrugResearch, Shanghai Institute of Materia Medica, Shanghai Institutes for
Biological Sciences, Chinese Academy of Sciences, Shanghai 201203,
China.
2CorrespondingAuthor: State Key Laboratory of Drug
Research, Shanghai Institute of Materia Medica; Shanghai Institutes for
Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road,
Zhangjiang Hi-Tech Park, Shanghai 201203, China. Tel: +86-21-50806701,
Fax: +86-21-50806701, E-mail: jpzuo@mail.shcnc.ac.cn.
This study was undertaken to have a better understand for the process and the underlying mechanisms to limit
macrophage activation and population of activated macrophages. A comprehensive kinetics of cytokine
production was performed in murine peritoneal macrophages recovered from Balb/c mice at various time
during the course of an intraperitoneal injection with thioglycollate (TG). The expression of cell surface
molecules such as MHC-I, MHC-II, B7-1 and B7-2 of these macrophages were also determined by flow
cytometry. The present findings of our research suggested that the population of activated macrophages and the
activation of macrophages (including cytokines production and expression of cell surface functional molecules)
were strictly controlled during inflammation process. This is one of the important mechanisms to retain the host
homeostasis.
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